Jo Anne Powell-Coffman

Jo Anne Powell-Coffman, Ph.D.
Associate Professor
Genetics, Development, and Cell Biology Dept
Office: 515.294.3906
Email: japc@iastate.edu
Dept homepage: http://www.gdcb.iastate.edu/faculty/facultyDetail.php?id=100
Research homepage:
http://www.public.iastate.edu/~japc/homepage.html

Education and Post-doctoral Training

Post-doctoral research, University of Colorado at Boulder
Ph.D., Biology, University of California at San Diego
B.S., Physiology, University of California at Davis

Role in ADVANCE program

ADVANCE Professor, GDCB Department

Research Interests
The Powell-Coffman research group employs a powerful genetic model system, the nematode C. elegans, to study how animals sense and adapt to their environment. Currently, the lab's research is focused on two biomedically important transcription factors: the aryl hydrocarbon receptor (AHR) and the hypoxia-inducible factor (HIF).

Selected Publications
Shen, C., Shao, Z., and J. A. Powell-Coffman. (2006). The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Genetics 174(3):1205 - 1214.

Qin, H., Zhai, Z., and J. A. Powell-Coffman. (2006). The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Developmental Biology 298(2):606 - 615.

Shen, C., Nettleton, D, Jiang, M., Kim, S. and Powell-Coffman, J.A.. (2005). Roles of HIF-1/hypoxia inducible factor and VHL-1/ Von Hippel tumor suppressor during hypoxia response in C. elegans. J. Biol. Chem 280:20580-8.

Huang, X., Powell-Coffman, J. A., and Y. Jin. (2004). Specification of GABAnergic subtypes by the AHR-1 aryl hydrocarbon receptor complex in C. elegans. Development 131: 819-28.

Qin, H. and Powell-Coffman, J.A.. (2004). Regulation of neuronal development by AHR-1, the C. elegans aryl hydrocarbon receptor. Developmental Biology 270: 64-75.

Powell-Coffman, J.A.. (2003). bHLH-PAS proteins in C. elegans. In, PAS Proteins: Regulators and Sensors of Development and Physiology (Editor S. Crews). Kluwer Academic Publishers. Norwell, MA. pp 51 - 68 .

Jiang, H., Guo, R., and J. A. Powell-Coffman. (2001). The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc. Natl. Acad. Sci. U. S. A. 98: 7916 - 7921.